Image Recognition
Tokyo [Japan], August 21 (ANI): Multiple research in animal models have shown that melatonin and its compounds improve memory. In addition, they examined “phosphorylation,” or the biochemical addition of phosphate groups to protein structures, in five key proteins involved in memory formation. Initial experiments conducted on male mice clearly showed that the administration of melatonin, ramelteon, or AMK at a dose of 1 mg/kg facilitated the formation of long-term memory. The amount of time spent by the mice exploring each object—a good measure of object recognition memory—was recorded by a trained observer. In the perirhinal cortex (PRC), which is also associated with memory functions, both ramelteon and AMK significantly increased ERK, and only ramelteon significantly increased CaMKIIβ phosphorylation.