Image Recognition
Extracellular signal-regulated kinase (ERK), calcium/calmodulin-dependent kinase II (CaMKII), CaMKII, CaMKIV, and the cAMP-response element binding protein (CREB) were among them. Initial studies on male mice clearly demonstrated that administration of melatonin, ramelteon, or AMK at a dose of 1 mg/kg aided in the formation of long-term memory. Long-term memory formation in male mice was evaluated through a series of experiments based on the novel objection recognition task, or "NORT." A trained observer recorded the amount of time the mice spent exploring each object, which is a good measure of object recognition memory. These drugs, however, significantly reduced CaMKII/ phosphorylation in the same brain region.