Protein essential for effective bacterial immune response

Endotoxin bacterial lipopolysaccharide (LPS)is a driver of lethal infection sepsis through excessive activation of innate immune responses. The research focused on macrophages, immune cells that absorb and digest pathogens and increase the activity of other immune cells. The gene’s NLRP11 protein allows a macrophage to detect the presence of bacterial lipopolysaccharide molecules within its core. These NLRP11 actions result in an effective immune system defense that kills invading bacterial cells and prevents widespread infection in the body. These NLRP11 actions result in an effective immune system defense that destroys invading bacterial cells and keeps the body from becoming infected.